Resveratrol (RES), a non-flavonoid polyphenolic compound present in plants, is widely used in cosmetics for its obvious antiplatelet aggregation, antibacterial, anti-aging and hypolipidemic effects. However, RES contains a polyphenolic structure with conjugated double bonds, is easily oxidised, is photostable, and has poor water solubility, low bioavailability (less than 1%) and short in vivo circulation time, which are drawbacks that greatly limit its application. To overcome these problems, researchers have used flexible nanoliposomes to encapsulate resveratrol to increase its content and bioavailability in formulations.
In the field of cosmetics, both resveratrol nanoemulsions and flexible nanoliposomes have shown promising applications. They can serve as effective carriers to deliver resveratrol to the deeper layers of the skin and continuously release the active substances, thus exerting antioxidant and anti-aging effects. In addition, nanoemulsions and flexible nano-liposomes have the effect of improving skin texture, moisturising and nourishing the skin, which can enhance the overall quality and use of cosmetics.
In addition to applications in cosmetics, resveratrol nanoemulsions and flexible nanoliposomes also have potential in the pharmaceutical field. They can be used as drug delivery systems to improve the solubility, stability and bioavailability of drugs, thereby enhancing therapeutic effects and reducing side effects.
Resveratrol Nano Emulsion
Nanoemulsions are transparent or semi-transparent, low-viscosity, thermodynamically stable systems composed of water, oil, surfactant and co-surfactant, which have the advantages of small particle size, good stability and biocompatibility.
The preparation of resveratrol nanoemulsions usually involves steps such as emulsification and high-pressure homogenisation, etc. By optimising the formulation and process parameters, a nanoemulsion system with uniform particle size and good stability can be obtained. Such systems can not only improve the water solubility and bioavailability of resveratrol, but also enhance its biological activities such as antioxidant and anti-inflammatory.
Resveratrol flexible nanoliposomes
Flexible nanoliposomes are formed by adding an appropriate amount of surfactant to conventional liposomes, which makes the liposome membranes have higher deformation ability to penetrate the skin and reach the deep tissues. In addition, flexible nanoliposomes have good hydrophilicity and moisturising effect, which makes them have a broad application prospect in the field of cosmetics.
Resveratrol flexible nanoliposomes are usually prepared by injection method, and by optimising the types and ratios of phospholipids, cholesterol and surfactants, a system with good stability and high loading can be obtained. Such systems can not only improve the bioavailability of resveratrol, but also reduce its irritation and enhance its efficacy in cosmetics.
Yocell High Pressure Homogeniser Preparation Advantages:
➤ Effective reduction of emulsion particle size - makes the emulsion finer and the ingredients more evenly dispersed, improving the quality and stability of the product;
➤ Enhancement of encapsulation rate - the active ingredient is evenly encapsulated inside the liposome, maintaining its activity and stability;
➤ Improve production efficiency - the equipment is easy and convenient to operate, and can quickly complete the process of emulsion/liposome preparation;
➤ Complete equipment - Yocell provides all sizes of production equipment from R&D to production to meet customers' needs at different stages.
